Dark Spot^Rx

In the morning and evening, apply a thin layer to freshly cleansed skin on affected areas, as directed by your medical provider. For small spots, apply directly with a cotton swab. For larger areas of hyperpigmentation, apply a thin, even layer using your fingertips. Follow with moisturizer and wear SPF every day.

Because Dark Spotᴿˣ is a personalized treatment, your medical provider may adjust your formula over time, including cycling between hydroquinone and non-hydroquinone formulas when appropriate.

As part of your treatment plan, your medical provider will periodically transition you from a hydroquinone formula to a non-hydroquinone formula with azelaic acid. This approach helps your medical provider continue targeting dark spots, melasma, and uneven skin tone while tailoring treatment to your skin's needs over time.

Dark Spotᴿˣ is different from over-the-counter dark spot treatments because it is a personalized, prescription-strength treatment that may include hydroquinone – an ingredient that is not available in over-the-counter skincare. Hydroquinone is a prescription ingredient for fading the appearance of dark spots by targeting excess melanin production. Dark Spotᴿˣ can offer up to 3x higher hydroquinone strength than a traditional pharmacy, making it a more potent, targeted option for stubborn discoloration, melasma, and uneven tone. Your medical provider will determine whether hydroquinone is right for your skin and prescribe a formula based on your skin goals. *Not all Dark Spotᴿˣ formulas contain hydroquinone. Subject to medical consultation.

Yes. Hydroquinone and azelaic acid are often used together because they work in complementary ways to help improve the appearance of dark spots, melasma, and uneven skin tone. Hydroquinone helps reduce excess melanin production to fade the appearance of discoloration, while azelaic acid helps promote a more even-looking complexion. Together, they provide a targeted approach to treating hyperpigmentation. *Not all Dark Spotᴿˣ formulas contain hydroquinone. Subject to medical consultation.

Yes. Dark Spotᴿˣ can be used with retinoids, including prescription tretinoin, as part of your skincare routine. Your personalized treatment plan may include Night Renewᴿˣ, a prescription treatment that can contain tretinoin if right for you. If you're using Night Renewᴿˣ and Dark Spotᴿˣ together, follow your medical provider's guidance on when to use each product, the order to apply them, and how often to use them to help minimize irritation while supporting your skin goals.

Yes. Sunscreen is one of the most important steps in any hyperpigmentation treatment routine. UV exposure can make dark spots, melasma, and uneven tone look more noticeable. Wearing sunscreen every day helps support your treatment and maintain your results over time. Pair Dark Spotᴿˣ with SilkScreen, Agency's broad-spectrum SPF 50 mineral sunscreen with a sheer tint designed to blend smoothly into skin.